SCWTCA ENDOWMENT, INC. –
SUPPORTING WHEATEN HEALTH, RESEARCH, AND EDUCATION

•SCWTCA Endowment Origins

  • 1995 established the SCWTCA Health Fund

  • 2001 created a separate non-profit

  • 2004 incorporated as the SCWTCA Endowment, Inc.

  • 2006 gained 501(c)3 status

•Ongoing Fecal A1PI Kit Program

This kit was created to eliminate the owner’s cost of a vet submitting samples to the TAMU GI Lab and to insure the samples arrived frozen to the lab for accurate testing of intestinal protein loss. The kit continues to be made available by the SCWTCA Endowment, Inc. at manufacturer’s cost. Distribution points set throughout the US & Canada.

Approved by SCWTCA, Inc.; Distributed by the SCWTCA Endowment, Inc.

•2002 & 2004 AKC-CHF Grant 2219: Longitudinal Clinical Study, Mode of Inheritance and Therapeutic Trial of PLE/PLN in Soft Coated Wheaten Terriers

From birth comparison of SCWTs fed hypoallergenic diet with SCWTs fed normal diet. AKC-CHF provided oversight for grant administration. SCWTCA matched funds for two prior related grants starting in 1996.

Researcher: Shelly Vaden DVM PhD DACVIM, North Carolina State University

Funding: $55,600 Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

•2003, 2004 Adopt a Colony Dog Fundraiser

The Colony Dogs living at NC State University were used in numerous research grants to Dr. Shelly Vaden starting in 2003. This project was a coordinated fundraising campaign among individual and regional clubs to support the dogs’ daily care and well-being. Gifts were solicited by the Endowment and paid directly to NCSU Veterinary Medical Foundation.

Researcher: Shelly Vaden DVM PhD DACVIM North Carolina State University 
Funding: $13,300 for expenses. Approved by SCWTCA, Inc.; Funded by the SCWTCA Endowment, Inc. $145,450

•2006 AKC-CHF: Genetic Determinants of Malignant Melanoma

Researcher: Michael Kent DVM, University of California - Davis

Funding: $1,000. Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

•2006 Investigation of Antigenic Causes of Vaccine-Associated Allergic Reactions in Dogs

Researcher: Dr. George Moore, Purdue University.

•2006 4th Annual AKC-CHF Canine Cancer Conference: Genes, Dogs, & Cancer

Several prominent researchers. Addressed identifying genetic markers for specific diseases and possible avenues to find new therapies to combat diseases. Helped sponsor the conference; received complementary registration for two conference attendees.

Attendees: Elaine Azerolo and Susan McGee.

Funding: $5,000. Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

•2007 & 2008 University of Missouri Canine Phenome Project

The purpose of the Canine Phenome Project: to establish a DNA bank with supporting data for use by researchers to identify the genes responsible for canine diseases and other characteristics. For Wheaten owners, an opportunity to store DNA from Wheatens for future use by researchers interested in finding the genetic cause of PLE, PLN, RD, Addison's, and/or other diseases. NIH Lifetime Study and Siblings Pair Study included.

•2007-2008 National Institutes of Health: Lifetime Study of the SCWT

Seven of the 21 blood draw clinics described above provided 103 samples for the NIH study.

Researcher: Dr. Elaine Ostrander, Ostrander Canine Genomics Lab, Bethesda, MD

•2008 AKC CHF Conference

Attendee: Jana Carraway

Funding: $200 Approved by SCWTCA Endowment, Inc.

•2008 Informative Family Project, Geriatric Dog Project contributing to AKC-CHF Grant 1485: Longitudinal Field Studies of Families of SCWTs Affected with PLE and/or PLN and the Foundation of a DNA Bank

Pelletizing DNA for Penn DNA Bank; biopsies; shipping of samples; summer students; genetic testing DNA collection kits; AKC report fees for Penn for registration numbers; histopathology, testing expense; freezer expense.

Researcher: Meryl P. Littman VMD DACVIM, University of Pennsylvania

Funding: $9,000. Approved by SCWTCA, Inc.; Funded by the SCWTCA Endowment, Inc. $5000 and

$38,800

•2009 Sibling Pairs Study SNIP Chip Purchase

Technology to compare 24 pairs of affected and non-affected SCWT siblings. Includes Blood Draw Clinics (Paid 1/3 of the cost to help sponsor 21 blood draw clinics to acquire DNA samples for the CPP.) and SNIP CPP Participant Fee Sharing (Paid 1/2 of the participant registration fee for 991 SCWTs whose blood was drawn during SCWTCA sponsored clinics to produce DNA samples for future Wheaten-related research.)

Researcher: Gary Johnson DVM Ph.D., University of Missouri - Columbia

Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc. $35,200

•2009 Rabies Challenge Fund Charitable Trust

Private fund supporting longitudinal work to address the duration of immunity conveyed by rabies vaccine with the intent of extending the legally required interval for rabies boosters to 5, then 7 years.

Researcher: Dr. Ronald Schultz, University of Wisconsin-Madison

Funding: $500. Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

•2009 AKC-CHF Parent Club Health Conference

Various presenters addressing health issues applicable to most breeds.

St. Louis, MO

Attendee: Jana Carraway

Funding: $200. Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

•2012 Student Researcher Professional Development Award

This award supports vet students who make significant contributions to health-related research projects involving SCWTs by partially funding their attendance to a professional conference to present results from a project they worked on. In 2012, an award was made to Claire Wiley to support her presentation of the Genome-wide Association Study of PLN.

Grant Recipient: Claire Wiley

Funding: $560. Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

•2012 Genome-Wide Association Study (GWAS) of Protein-Losing Nephropathy (PLN) in Soft Coated Wheaten Terriers—Genetic Testing for PLN-Associated Variant Genes

After years of research supported by the owners and breeders of hundreds of Wheatens throughout the world, Dr. Meryl Littman and Dr. Paula Henthorn at the University of Pennsylvania School of Veterinary Medicine (Penn Vet) identified mutations associated with PLN in two genes.

Samples from the PennVet SCWT DNA Bank were used in a genome-wide association study (GWAS) using 177,000 single nucleotide polymorphisms (SNPs), of which 81,097 SNPs were informative. Control dogs (unaffected Wheatens aged 14 – 18) and affected dogs were studied, as were dogs of other breeds. PLN was found to be associated with changes in two genes responsible for encoding the proteins found in the podocyte slit diaphragm, a fundamental component of the glomerular filtration barrier in the kidney. For more information, please see the Research Abstract as well as the peer-reviewed research report published in Mammalian Genome in January 2013.

The research resulted in a DNA cheek swab test, introduced to Wheaten owners in May 2012. DNA collection kits were made available worldwide at no cost to SCWT owners and breeders to assist Drs. Littman and Henthorn in gathering 1,000 SCWT DNA samples for a prevalence study between May and September 2012. The SCWTCA, Inc., the SCWTCA Endowment, Inc., and the Genetic Research Fund combined efforts to finance this project.

After the introduction of the test in 2012, SCWTCA, the Endowment, and the Genetic Research Fund Boards, issued a Statement on Genetic Testing for PLN-Associated Variant Genes endorsing testing for PLN-associated variant genes by breeders and stud dog owners as one tool in the assessment of breeding stock. Testing information and information guides can be found on the DNA testing page of The SCWT Club of America website.

In 2016, the membership of the SCWTCA voted to amend its Code of Ethics to require use of this test prior to breeding.

Researchers: Claire A. Wiley, Meryl P. Littman, Michael G. Raducha, Paula S. Henthorn, University of Pennsylvania School of Veterinary Medicine

•2013 Tufts University Breeding & Genetics Conference:

Attendee: Deb Van De Ven

Funding: $235. Approved by SCWTCA, Inc.; Funded by SCWTCA Endowment, Inc.

•2013 Purchase and Maintenance of SCWT Health and Pedigree Database

After a number of years of development, the SCWTCA Endowment, Inc., was excited to announce in 2018, the launch of the Soft Coated Wheaten Terrier Health and Pedigree Database. This database set-up was originally developed by the Berner-Garde Foundation 30 years ago and is in use by several other breeds in addition to Wheatens. Starting with San Jeffries’s database of 46,000 dogs, a team of volunteer data operators added dogs resulting in a debut of nearly 60,000 Wheatens from around the world. 

Initial Funding: $7,600

•2014 Trustees of the University of Pennsylvania School of Veterinary Medicine SCWT Histopathology & Testing Expense

Funding: $5,000

•2015 Freezer Storage University of Pennsylvania, School of Veterinary Medicine

Purchase of a new freezer to store SCWT DNA samples Trustees of the University of PA School of Veterinary Medicine

Funding: $9,142

•2016 Pilot Association Study of PLE/PLN (Protein-Losing Enteropathy/Nephropathy) in SCWTs

Nearly one hundred DNA samples, including both “affected” and “normal control” dogs, were chosen for initial analysis by the Section of Medical Genetics at the University of Pennsylvania School of Veterinary Medicine. These samples were subjected to a new technology that assays thousands of single-nucleotide polymorphisms (SNPs) simultaneously.

Researchers: Meryl P. Littman, Paula S. Henthorn, University of Pennsylvania

Funding: $9,000. Approved by SCWTCA, Inc.; Funded by the SCWTCA Endowment, Inc. and the Meryl P. Littman Wheaten Fund supported through the generosity of Dr. Littman’s clients and Wheaten friends.

•2018 AKC CHF Grant 2519: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas within and between Geographic Locations:

Researcher(s): Edward B Breitschwerdt DVM; Matthew Breen PhD; North Carolina State University.

Funding: $2,500. Funded by the SCWTCA Endowment, Inc.

•2019 Genome-Wide Association Studies (GWAS) using SNP chips for Protein Losing Enteropathy (PLE)

Genome Wide Association Studies to identify the chromosomal regions (and genes within these regions) that are associated with PLE or PLN and can then be studied in additional dogs for confirmation.

Researcher: Paula Henthorn PhD BS, Mariah Gentry, DVM at University of Pennsylvania School of Veterinary Medicine

Funding: $7,750.

•2019 Genetic Testing for PLN-Associated Variant Genes Follow Up Survey

Researchers: Paula Henthorn PhD BS, Mariah Gentry DVM, University of Pennsylvania School of Veterinary Medicine

Funding: $5,000

•2019 Whole Genome Sequencing (WGS)

Since the introduction of the DNA test for PLN risk, owners and breeders have continued to hope for some similar testing for PLE. As noted, it is a more complex disease. WGS is an important component of this research.

WGS identifies essentially ALL of the DNA variants in an individual (there are millions of DNA variants within an individual mammal, compared to another member of the same species). The overall goal of WGS (combined with other information) is to identify all of the DNA variants in healthy and disease affected dogs, then to find which of those variants are associated with disease. This is done by analyzing the genome sequences by comparing to sequences of other dogs, examining genes known to be involved with the particular or similar diseases, such as inflammatory bowel diseases for PLE, and by performing GWAS (genome-wide association studies with SNP chips) to point to the chromosomal regions that need to be studied. The goal of the proposed studies, in combination, is to further improve our ability to predict the occurrence of PLN. Dr. Henthorn has submitted 10 dogs for WGS sequencing to advance to our understanding of both PLE and PLN.

Researcher: Paula Henthorn PhD BS, University of Pennsylvania

•2020 Ectopic Ureters

Use of laser ablation techniques on a test case to further understand and expand our knowledge of Ectopic Ureters in the SCWT.

Researcher: Daniel Langlois BS DVM DACVIM, Michigan State University College of Veterinary Medicine

Funding: $1,600

•2020 PLN Gene Testing – 2 vs 1

Testing for variant alleles associated with a risk for PLN ("DNA test") was initially developed at Penn based on Drs. Littman and Henthorn's research. That research showed that a DNA variant occurred in each of two genes, NPHS1 and KIRREL2, that are next to each other in their position on dog chromosome 1, and that the presence of these two variants on both copies of chromosome 1 indicated significantly increased risk for developing PLN (Protein-Losing Nephropathy). Among the well over 4,000 Soft Coated Wheaten Terrier samples that Penn has analyzed since the test was introduced in 2012, there have been three (3) Wheaten terriers with results in which both genes had different genotypes, (for example 1-1 for NPHS1 and 1-2 for KIRREL2). In these cases, Penn reports the results more specifically, and discusses the ramifications of these results with the dog’s owner.

•2020 AKC CHF Grant 02800: Defining the Effect of Genotype, Breed and Age on the Risk of Developing Canine Degenerative Myelopathy and Investigating the Molecular Mechanisms Underlying that Risk

The Endowment, together with the SCWTCA and the SCWT Genetic Research Fund, is donating to the funding for this grant. Together with mixed breeds and 30 other breeds, Wheatens are susceptible to DM, a late-onset progressive neurodegenerative disease.

•2020 Genetic testing for Degenerative Myelopathy (DM) and Microphthalmia

The University of Pennsylvania's PennGen testing facility has announced the availability of genetic testing for DM and Microphthalmia, a condition involving eye abnormalities and blindness. Penn's research into PLN in Wheatens resulted in genetic testing for the variant alleles associated with risk of PLN and has been offering testing to owners since 2012. The Endowment, together with the entire Wheaten community, supported the research leading to the PLN testing. Owners can now obtain all three tests through PennGen. Read the PennGen announcement PDF at the PLN Testing Recommendations page.

•2020 Dr. Paula Henthorn's June SCWT PLE/PLN Research Progress Report

1. Survey

A 91-question survey was developed and distributed (in three phases) to owners and breeders, beginning early this year. A single survey was sent for each of 3773 dogs that had been tested using the PLN-Associated Variant Genes Test (and thus, we have DNA for these dogs). 2. Sequencing dogs for studies of both PLE and PLN

The Animal Health Trust in England has sequenced two dogs, including one healthy 13-year-old SCWT. Sequencing of 10 additional dogs has been completed, and the data files transferred to our laboratory. All 12 of these dogs will be useful for the study of PLE, with some of the dogs also useful for studies that may enhance genetic testing for PLN. The analysis will go into full swing when we can get access to the computer that we need for the analysis. (All non-essential research was suspended starting March 18th, and limited access to our laboratories is now being phased in.)

3. GWAS (Genome Wide Association Study, using SNP chips)

This phase is on hold until we identify additional dogs for GWAS analysis, based on information from steps 1 and 2 above.

4. Offer additional genetics tests for use by SCWT breeders: DM (Degenerative Myelopathy)
and Microphthalmia

Two genetic diseases that have been identified in Wheaten Terriers are listed above. We have developed assays for these tests and now offer them through the PennGen laboratories. We have created two documents (one to announce the test availability, and one to explain the genetics of microphthalmia in SCWT, based on the study performed in Finland (Kaukonen et al. 2018 Cell Reports 23(9):2643-2652). To determine if this disease variant allele is present in the North American SCWT population, we tested 66 of the DNA samples derived from PLN testing. Fifteen percent (10 of 66 samples) tested as carriers for the disease-associated variant in the RPB4 gene. (Among these samples were 48 samples that were received after mid-November 2019. Five of these recent samples were carriers.) None of the 66 samples had two copies. This is a small sample size, but it does demonstrate that this disease-causing gene variant is present in the SCWT population. Genetic testing, particularly of any female that is being considered for breeding, will allow breeders to avoid affected puppies in their breeding programs.

Finances (by numbered activities above)

1. $15,500 was contributed from the SCWTCA and the SCWT Endowment ($7,750 each)

2. $10,000 was contributed from the SCWTCA and the SCWT Endowment ($5,000 each) for ten dog genome sequences, with $8,000 directly available for this project.

3. The estimate of the cost for this part of the research was originally estimated at $10,000, although costs will be re-examined as the scope of the necessary work becomes clearer.

4. All costs for the development of the assays, and initial screening for microphthalmia were completely covered by the PennGen laboratories, including technician and faculty salaries.

•2021 Grant #02428: Identifying Disease-defining Autoantibodies in Canine Addison’s Disease

Here are Grant #02428 project details.

Researcher: Steven G Friedenberg DVM, PhD, University of Minnesota

Funding: $3,000.

Research Update Report PDF: August 2021

•2021 Grant #02534: Clinical Evaluation of Propranolol in Combination with Doxorubicin for the Treatment of Hemangiosarcoma

Here are Grant #02534 project details.

Funding: $3,000

•2021 Grant #02658: Characteristics of Sensory Neuronal and Muscle Pathology in Canine Degenerative Myelopathy to Identify Targets for Therapeutic Intervention

Here are Grant #02658 project details.

Funding: $3,000

•2022 NCVMF Dr. Katie Tolbert PLE Research Study

Funding: $5,000

•2022 DNA Testing Rebate Program (offset cost to 159 owners using PLN DNA Test)

Funding: $3,180

•2023 Trustees of UofPA-PennGen: Paroxysmal Dyskinesia (PdX) Test Development

Funding: $2,500

•2023 DNA Testing Rebate Program (offset cost to 100 owners using PLN DNA Test)

Funding: $2,000

•2024 NCVMF: Dr. Katie Tolbert & Dr. Kylie Grant Chronic Kidney Disease & GI Bleed Study

Funding: $19,355

•2024 DNA Testing Rebate Program (offset cost to 28 owners using PLN DNA Test)

Funding: $560

Wheaten Webinars

2021, the SCWTCA began offering educational Wheaten Webinars on a variety of topics, including health issues.

•02/16/2021 Wheaten Webinar • Coat Color Genetics in Wheatens

Presenter: Dr. Neil O’Sullivan, noted geneticist and longtime Wheaten breeder

03/16/2021 Wheaten Webinar • Exploring the SCWT Database

Presenter: Anna Marzolino, Chair of the SCWTCA Endowment, Inc.

04/20/2021 Wheaten Webinar • Dawn of DNA Testing

Dawning of the age of DNA testing — where to test, what does it mean, and adding the information to the SCWT Database

Presenter: Dr. Neil O’Sullivan, noted Geneticist and longtime Wheaten breeder

  • Lin•05/18/2021 Wheaten Webinar • Gulpies, IBD, & Food Allergies

Presenter: Meryl P. Littman VMD DACVIM

Sponsored By: SCWTCA Endowment, Inc. $750

•06/15/2021 • Best Practices for Managing The Stud Dog — Let’s Hear It For The Boys!

Presenter: Erin E. Runcan DVM DACT, The Ohio State University College of Veterinary Medicine

Sponsored By: SCWTCA, Inc & SCWTCA Endowment, Inc.

•07/20/2021 Wheaten Webinar • CHIC, Genetic Tests, & Summertime Thoughts

Presenters: Susan Ratliffe, Beth Sorenson, Elaine Azerolo, Cyndi Stokvis, & Neil O’Sullivan

Sponsored By: SCWTCA Health Committee

•July 2021 The Endowment, Inc. Survey — The Gulpies and Digestive issues in Wheatens

The Endowment created and conducted a survey on the Gulpies and Digestive issues in Wheatens with over 1,200 responses. See the Gulpies Survey Results PDF.

•08/17/2021 Wheaten Webinar • Microphthalmia

Presenter: Gustavo Aguirre VMD PhD PhD(hc), American College of Veterinary Ophthalmologists Professor of Medical Genetics and Ophthalmology, University of Pennsylvania School of Veterinary Medicine

Sponsored By: SCWTCA, Inc.

•09/21/2021 Wheaten Webinar • Temperament & Rage Syndrome

Presenter: Karen Overall MA VMD PhD DACVB; Editor in Chief, Journal of Veterinary Behavior: Clinical Applications and Research

Sponsored by: SCWTCA, Inc.; SCWTCA Endowment, Inc. $350, SCWTCA Health Committee

•10/26/2021 Wheaten Webinar • Ectopic Ureters/Urogenital Disorders in Wheatens

Presenter: Julie Byron DVM MS DACVIM; Professor, Clinical Small Animal Internal Medicine, Ohio State University — College of Veterinary Medicine

Sponsored By: SCWTCA, Inc. & SCWTCA Endowment, Inc., SCWTCA Health Committee

•11/10/2021 Annual Health Testing Protocols updated

Annual Health Testing Protocols have been updated and approved by Dr Littman. This PDF handout can be printed and given to your vet and kept in their file. This will ensure that you get all the proper health testing completed at the time of the visit and won't have to go for subsequent visits. As you can see, Dr. Littman has recommended that ALL Wheaten Terriers have the DNA Test for the PLN Variant Gene. She has listed the companies that have made the test available to the general public.

As someone on the SCWTCA Health Committee stated, "A Urinalysis is a Wheaten's best friend." A good thing to remember!

•11/16/2021 Wheaten Webinar • PLN/Kidney Disease Update

Presenter: Meryl Littman VMD DACVIM

Sponsored By: SCWTCA, Inc., SCWTCA Endowment, Inc., SCWTCA Health Committee

★12/3/2021 — Wheaten Health Newsletter inaugural annual issue!

PDF of Inaugural Wheaten Health Newsletter

•02/15/2022 Wheaten Webinar • Optimum Age for Spay and Neuter

Presenter: Erin E. Runcan DVM DACT, Assistant Professor of Theriogenology & Reproductive Medicine, The Ohio State University College of Veterinary Medicine

Sponsored By: SCWTCA, Inc. & SCWTCA Endowment, Inc.

•03/15/2022 Wheaten Webinar • Orthopedic Issues in Wheatens

Presenter: Darryl Millis MS DVM DACVS CCRP, Professor of Orthopedic Surgery, University of Tennessee at Chattanooga College of Veterinary Medicine

Sponsored By: SCWTCA, Inc & SCWTCA Endowment, Inc.

•04/19/2022 Wheaten Webinar • The Unique Soft Coated Wheaten Terrier – Head/Ear Characteristics

Presenter: Cindy Vogels

Sponsored By: SCWTCA, Inc & SCWTCA Endowment, Inc.

•05/17/2022 Wheaten Webinar • C-BARQ, The Canine Behavioral Assessment & Research Questionnaire

Presenter: James Serpell PhD Emeritus Professor of Animal Welfare, School of Veterinary Medicine University of Pennsylvania

Sponsored By: SCWTCA, Inc & SCWTCA Endowment, Inc.

C-BARQ is a standardized behavioral evaluation tool. This can be a reliable, validated method for measuring behavior problems in dogs.

You can sign up as pet owners and take the questionnaire on 1-3 of your dogs, if you like. You will need this six-digit code to access the account: 758847. There is no charge or fee for this as the SCWTCA Endowment Inc. has set up an account link for us.

  1. Click on "Sign Up Today" and create a brief profile.

  2. Next, enter a dog by clicking on "Add a Dog."

  3. Then, select "Dog is participating in a study" and click "Next".

  4. Select the name of your organization: "SCWTCA Endowment Inc." and provide this six-digit code: 758847.

  5. Complete the questionnaire on your dog(s). An analysis will be sent to you.

•06/28/2022 Wheaten Webinar • Early Intestinal Disease Marker Study

Presenter: Katie Tolbert DVM, North Carolina State University School of Veterinary Medicine

Sponsored By: SCWTCA, Inc., SCWTCA Endowment, Inc., and the Health Education Committee

This new SCWT study at NCSU hopes to identify dogs with PLE before there are Blood Work Changes.

•07/8/2022 SCWT Early Intestinal Disease Marker Study

Wheaten Terriers diagnosed with PLE and healthy Wheaten Terriers are needed for a study with NC State University School of Veterinary Medicine. NCSU is beginning a study it hopes will identify SCWTs with PLE before there are any clinical bloodwork changes. Participation is specific: 8-10 “normal” Wheatens and 8-10 “affected” Wheatens are needed. Testing is done free of charge at NCSU in Raleigh, NC. There are financial incentives. For more information, contact Katie Tolbert DVM.

•08/16/2022 Wheaten Webinar • Degenerative Myelopathy

Presenter: Liz Hanson, DNA Research Information Specialist, University of Missouri College of Veterinary Medicine Genetics Lab

Sponsored By: SCWTCA, Inc. & SCWTCA Endowment, Inc.

•09/20/2022 Wheaten Webinar • What Makes The SCWT Unique – Presentation

Presenter: Cindy Vogels. Chair of the SCWT Breeder Education Committee, AKC Judge.

Sponsored By: SCWTCA, Inc. & SCWTCA Endowment, Inc.

•2023 SCWT Early Intestinal Disease Marker Study

Wheaten Terriers diagnosed with PLE and healthy Wheaten Terriers are needed for a study with NC State University School of Veterinary Medicine. NCSU is beginning a study it hopes will identify SCWTs with PLE before there are any clinical bloodwork changes. Participation is specific: 8-10 “normal” Wheatens and 8-10 “affected” Wheatens are needed. Testing is done free of charge at NCSU in Raleigh, NC. There are financial incentives. For more information, contact Katie Tolbert DVM at mktolbe2@ncsu.edu.

Participation Information Form

•2023 Jablonski Research Program — Evaluating New Diagnostics & Treatments for PLE

Dr. Sara Jablonski is studying how to better diagnose and treat Protein-Losing Enteropathy (PLE) in dogs. Both local and out-of-state clients may participate, as some studies require only 1 clinical visit. Clients whose dogs are part of 1 or more of Jablonski’s studies could save up to $2,500 on clinical services.

If you’re interested in applying for a PLE study with Jablonski, email sjw@msu.edu with information about your dog that will help determine their eligibility.

Please note: Jablonski and her collaborators are looking for dogs who have not seen prior treatment and, most importantly, have not been treated with steroids.

•September 2023 Wheaten Webinar • Renal Dysplasia and Interpreting Lab Values in Your Dog’s Bloodwork

Dr. Shelly Vaden, DVM, PhD, DACVIM. She is Professor Internal Medicine (Nephrology and Urology), Chief of Staff, Small Animal at North Carolina State University, College of Veterinary Medicine. She has been involved with our breed for many years. Bring your questions or submit them to me ahead of time to present to her before the Webinar. Her specialty is Urology. Read more about Dr. Vaden here: https://cvm.ncsu.edu/people/slvaden/.

Presenter: Dr Shelly Vaden, DVM, PhD, DACVIM at NCSU College of Veterinary Medicine

Sponsored by: SCWTCA Endowment, Inc.

Time: Sep 19, 2023 07:00 PM Eastern Time (US and Canada)

This was great a webinar. Dr. Vaden discussed lab values on dogs with Renal Disease, RD, PLE, PLN and those liver values that we have all been hearing about lately. She discussed the "chicken allergy" theory along with other food allergies, the Fecal API test on PLE dogs, Ectopic Ureters, the SDMA test and creatinine levels and the UPC ratio and systolic blood pressure (this was all really interesting), and the IRIS Treatment Recommendations for CKD, and possible non-genetic causes of PLN... what else am I missing?

If you didn't get a chance to watch the live Wheaten Webinar - Interpreting Lab Values, RD Update with Dr Shelly Vaden, DVM, you can watch it at your convenience! The Webinar is now available on the SCWTCA website. If you own a Wheaten, get the knowledge from the expert! Watch it at https://scwtca.org/education/webinars/.

*****Thank you to donors of the SCWTCA Endowment as your donations made this Webinar possible!*****

•December 2023 Wheaten Webinar • Phase 2 PLE Study in SCWTs

•February 2024 Wheaten Webinar • Addison’s Disease

Dr Meryl Littman did a Webinar on Addison’s Disease. Watch this important Webinar on Addison’s Disease, dubbed ”the Great Pretender” because it mimics symptoms of many other conditions. Get the latest updates on detailed diagnosing and treatment steps from an expert.

Presenter: Meryl Littman VMD DACVIM

Sponsored by: SCWTCA Health Committee, SCWTCA Endowment, Inc.

Time: Feb. 13, 2024 07:00 PM Eastern Time (US and Canada)

If you didn't get a chance to watch the live Wheaten Webinar - Addison’s Disease with Dr Meryl Littman, DVM, you can watch it at your convenience! The Webinar is now available on the SCWTCA website. If you own a Wheaten, get the knowledge from the expert! Watch it at https://scwtca.org/education/webinars/.

•March 2024 Wheaten Webinar • Does Chronic Kidney Disease Cause Gastrointestinal Bleeding in Dogs?

Researcher: Katie Tolbert, DVM, PHD, DACVIM-SAIM Clinical Associate Professor, Texas A&M University Gastrointestinal Laboratory

Funding: The Endowment has fully funded this study in the amount of $20,000.00. This research grant has the seal of approval from the SCWTCA Health Committee and SCWTCA Board of Directors.

 1   Abstract: Chronic kidney disease (CKD) is associated with an increased risk of upper gastrointestinal (GI)
 2   bleeding in humans, and hospitalized patients with CKD and GI bleeding are at a three times greater risk for
 3   in-hospital mortality. Limited research has explored whether these same risks exist in the veterinary
 4   population, and the prevalence of GI bleeding in dogs with CKD is unknown. Despite this knowledge gap, it
 5   is common for these patients to receive gastroprotectants to treat suspected GI bleeds, which not only
 6   increases medication burden for owners but also may be detrimental to dogs with CKD. Accordingly, the
 7   proposed study would be the first to evaluate GI bleeding in dogs with CKD compared to age-matched
 8   healthy dogs using video capsule endoscopy (VCE).

If you believe you have a dog that can participate in this study, please email Dr. Katie Tolbert at ktolbert@cvm.tamu.edu.

• August 2024 Wheaten Webinar • Update on PLE Research

Update on PLE Research, Katie Tolbert, DVM, PhD, DACVOM (SAIM, SA nutrition) will be speaking at a Zoom Webinar on Thursday August 15, 2024 at 7 pm EST. She will be talking about an update on the PLE research that she is doing. Her talks are always interesting and full of good information.

*Please note this Webinar is on Thursday evening and not our traditional Tuesday night per our speaker's request.

Presenter: Katie Tolbert DVM, PhD, DACVIM (SAIM, SA nutrition), Clinical Associate Professor, Gastrointestinal Laboratory, Small Animal Clinical Sciences, Texas A&M University

Sponsored by: SCWTCA Endowment, Inc.

Time: Aug 15, 2024 07:00 PM Eastern Time (US and Canada)

If you didn't get a chance to watch the live Wheaten Webinar - Update on PLE Research with Dr Katie Tolbert, DVM, you can watch it at your convenience! The Webinar is now available on the SCWTCA website. If you own a Wheaten, get the knowledge from the expert! Watch it at https://scwtca.org/education/webinars/.

•September 2024 Wheaten Webinar • Treatment Options For Dogs With Cancer

The Webinar this month is "Treatment Options For Dogs With Cancer: How surgery, radiation, chemotherapy and immunotherapy join forces." Dr. Selting is an Associate Professor at University of Illinois. She will also include information on Canine Hemangiosarcoma.

Presenter: Kimberly Anne Selting, DVM, MS, DACVR(Oncology), DACVR(Radiation Oncology)

Sponsored by: SCWTCA Endowment, Inc.

Time: Sep 17, 2024 07:00 PM Eastern Time (US and Canada)

If you didn't get a chance to watch the live Wheaten Webinar - Treatment Options For Dogs With Cancer with Dr Kim Selting, DVM, you can watch it at your convenience! The Webinar is now available on the SCWTCA website. If you own a Wheaten, get the knowledge from the expert! Watch it at https://scwtca.org/education/webinars/.

•Important for you and your vet! • November 2024 Wheaten Webinar • Leptospirosis

Not only for Wheaten Terriers but for all dog owners. We encourage you to attend this webinar and show your support and appreciation for Dr. Littman and Dr. Wiley. If you have questions on Leptospriosis diagnosis and vaccinations, please send them to health@scwtca.org and we will submit them to Dr. Littman directly.

“In a significant move, veterinary health authorities have updated the core vaccine recommendations for dogs to now include the leptospirosis vaccine. This update is particularly important for dog breeders, who play a crucial role in the health and well-being of future generations of dogs". - Claire Wiley, VMD DACVIM

Leptospirosis is on the rise in our country and a lot of the information we have on this vaccine is outdated regarding the improved version of this vaccine. Please join us for an update from an expert.

This webinar is dedicated to ‘Sprite’, ‘Rafferty’, ‘Emmy’ and ‘Pippa’ — all Soft Coated Wheaten Terriers that were affected with Lepto and subsequently succumbed to this infectious disease and whose owners reported the results to the SCWT Health and Pedigree Database to help other owners understand this infectious disease. It is also dedicated to ‘Molly’ who is a Lepto survivor and was cared for by Dr. Sara Jablonsky at Colorado State University School of Veterinary Medicine and who is heading up a PLE study now.

Presenter: Dr. Meryl Littman

Sponsored by: SCWTCA Endowment, Inc.

Time: Nov 14, 2024 07:00 PM Eastern Time (US and Canada)

If you didn't get a chance to watch the live Wheaten Webinar - Leptospirosis with Dr. Meryl Littman, you can watch it at your convenience! The Webinar is now available on the SCWTCA website. If you own a Wheaten, get the knowledge from the expert! Watch it at https://scwtca.org/education/webinars/.

•December 2024 Wheaten Webinar • Aopic Dermatitis in Wheatens

Do you have an itchy Wheaten or know of one?  The last Webinar of the year is with Dr. Ed Jazik DVM who is giving a talk on Atopic Dermatitis in Wheatens.  He is an expert in Dermatology for Animals.  Please join us before the Holiday season completely takes over.

Presenter: Dr. Ed Jazik DVM

Sponsored by: SCWTCA Endowment, Inc.

Time: Dec 3, 2024 07:00 PM Eastern Time (US and Canada)

If you didn't get a chance to watch the live Wheaten Webinar - Atopic Dermatitis in Wheatens with Dr. Ed Jazik, you can watch it at your convenience! The Webinar is now available on the SCWTCA website. If you own a Wheaten, get the knowledge from the expert! Watch it at https://scwtca.org/education/webinars/.

•December 2024 — Wheaten Health Newsletter and Update!

Dear Wheaten Owners:

Today is the 2024 Annual Day of Giving and this year we are going to change the rules and celebrate a Reverse Day of Giving. We are giving you great news and information on Wheaten Terrier health.

PLE History: In 1983 Emily Holden owned a bitch named CH Harwelden Beloved Amaden. She began to have severe edema, as did two of her offspring. There was no diagnosis for her condition. Emily consulted with pioneer Penn Vet Dr. Josephine Dueler, VMD who referred her to Dr. Meryl Littman VMD, DACVIM. With her dedication and knowledge a disease now had a name, treatment protocols and testing protocols were established and an Open Registry of affected dogs was created. But there is still work to be done. We need a genetic test for PLE, and that research is ongoing with committed Endowment funds at UPenn with Dr. Paula Henthorne, PhD Professor of Medical Genetics with Tenure - Clinical Studies & Advanced Medicine, University of Pennsylvania School of Veterinary Medicine Chief, Section of Medical Genetics, Department of Clinical Studies-Philadelphia School of Veterinary Medicine.

Today though is great day because we have the following announcement:

Royal Canin Research Grant: From M. Katherine ("Katie") Tolbert, DVM, PhD, DACVIM (SAIM, Board Certified Veterinary Nutritionist®) Associate Professor, Gastrointestinal Laboratory Small Animal Clinical Sciences: “Finally, we did get the Royal Canin grant to evaluate the effect of diet on GI health in Wheatens! As a reminder, we will be looking to enroll Wheatens that do not yet have a history of GI disease. The study lasts for about 3 months and there is free blood work, free video capsule endoscopy, and free food for the entirety of the study. We will start enrolling after the new year. I'll reach out with more information about the study then. We will start by enrolling dogs in the Raleigh, NC, College Station, TX, and East Lansing, Michigan areas but are hoping to branch out from there after we start the study”.

If you are a breeder in the North Carolina, Texas, Michigan area please reach out to your pet owners to help us find participants. If you are an owner and you think your Wheaten Terrier might be able to participate please contact health@scwtca.org and let us know of your interest.

The SCWTCA Endowment Inc. has pledged $40,000 towards this important research grant. The majority of the project is funded through Royal Canin. We hope to have a webinar to kick off the project in the near future so stay tuned. This is a SCWTCA approved research project.

Understanding PLN Testing: We have an updated PDF for you that was approved by Meryl P. Littman, VMD, DACVIM Professor Emerita of Medicine, University of Pennsylvania School of Veterinary Medicine. Understanding PLN and health testing has been a long process for many of us. This document should further clarify Annual Health Testing and PLN Variant Gene Testing and what their purpose is. Thanks to Pam Mandeville and Dr. Littman for their work on this document. Please send questions on the document to Anna Marzolino at marzolinoam@icloud.com or Pam Mandeville at bannerwheatens1980@gmail.com either one of us will be happy to help you.

SDS Page Test: Wheaten Terriers with an abnormal UPC should have a PLN Variant Gene Test performed and the SDS Page Test information is on this link. If you need assistance with DNA swabs to test your dog at the University of Pennsylvania School of Veterinary Medicine the Endowment offers free cheek swabs. Email Pam Tinnelly at Pamwaggintail@gmail.com to obtain your swabs.

Is It PLN or Lepto Webinar: The webinar was a great success. Thank you to Meryl Littman for her dedication to our breed and for sharing her knowledge with us. The webinar will be available this week on the SCWTCA website for you to review. Go to www.scwtca.org/education/webinars/ to watch this very important webinar.

Dermatology Webinar: We know the majority of health problems with any dog is Dermatology issues.  In the last Wheaten Health Survey it was the number one issue for our breed. So join us this evening to meet Ed Jazic DVM, Diplomate, American College of Veterinary Dermatology, Founder. Dr. Ed Jazic received his Bachelor of Science in Microbiology from the University of Toronto in 1994. He then earned his Doctorate of Veterinary Medicine from University of Illinois College of Veterinary Medicine in 1999. While at the University of Illinois, he served as president of the Theta chapter of Omega Tau Sigma and was active in community and social events. This event is free to you. If you were lucky enough to be at the last Lepto webinar you know how important it is to be there live. The Q & A after the event is very interactive. We hope to see you tonight. For those who signed up for a text message reminder I will send that out a half an hour before the webinar begins.

Chronic Kidney Disease Research Project: Dogs with Stage III & Stage IV Kidney disease based on the IRIS Kidney Staging Chart are needed for an important research project at North Carolina State University School of Veterinary Medicine. This project is fully funded by the SCWTCA Endowment Inc. and approved by SCWTCA Inc. Please read more here.

SCWT Health & Pedigree Database: There are 106,423 Soft Coated Wheaten Terriers entered in the database. If you have not entered your dog or updated their record please consider doing so. It is a great New Year’s Resolution. We are continuing the DNA rebate program for all DNA testing that is entered in the database.

Consults: We are very lucky to have had researchers and veterinarians dedicated to helping us with our dogs health concerns. Dr. Tolbert is a nutritionist and will consult with your veterinarian directly at a very low cost. You can reach her through the following protocols: “For more complicated cases where a medical review might be necessary to determine the most appropriate commercial diet, I do offer veterinary consultation services direct to the veterinarian - the charge is $120 for 20-40 minutes consultation directly with the veterinarian. We will also be offering nutrition appointments directly to owners by late January/early February. Owners who are interested in scheduling an appointment for this can reach out to vetnutrition@tamu.edu for scheduling information and pricing.”

Remember Dr. Littman consulted for over thirty years for free and she is now retired. Thank you to her for her dedication to us. Our breed was incredibly blessed to have her expertise.  

The SCWTCA Health Committee, the SCWTCA Endowment Inc. and SCWTCA are working hard for you and your Wheaten. Please let us know if you have questions or concerns or if you have an idea for a Webinar. You can reach the Health Committee at health@scwtca.org.

Happy Holidays and keep in touch. If you have holiday Wheaten photos, please send them to comments@scwtdb.org and we will try to use them. Don’t forget that Database New Years Resolution.

Sincerely,

Anna Marzolino
Chair, SCWTCA Endowment Inc.

•January 2025 Wheaten Webinar • Canine Pregnancy Nutritional Needs

Magda Chiarella of Dig’n Pop Norwich Terriers is an author, seminar presenter and a long time breeder. Her Canine Pregnancy seminar delves into the prenatal mechanisms and metabolic concerns of caring for the gestating dam. It is a hands-on seminar on what to feed, when, and why based on the interplay of nutrition and the functions of the body. These practices transform the way breeders care for their pregnant bitches and ensure the best foundation for a generational legacy of canine health.

Presenter: Magda Chiarella

Sponsored by: SCWTCA Endowment, Inc.

Time: Jan 21, 2025 07:00 PM Eastern Time (US and Canada)

If you didn't get a chance to watch the live Wheaten Webinar - Canine Pregnancy Nutritional Needs with Magda Chiarella, you can watch it at your convenience! The Webinar is now available on the SCWTCA website. Get the knowledge from the expert! Watch it at https://scwtca.org/education/webinars/.

•April 2025 Wheaten Webinar • Dr. Katie Tolbert Discusses the Upcoming PLE Study

Dr. Tolbert presents data on the upcoming PLE study and the hypothesis that diet might be the best strategy. She will answer questions about PLE and PLN in SCWT. By law, the Dr. cannot address specific questions about your dog without a patient/client relationship.

Presenter: Dr. Katie Tolbert

Sponsored by: SCWTCA Endowment, Inc.

Time: Apr 22, 2025 07:00 PM Eastern Time (US and Canada)

If you didn't get a chance to watch the live Wheaten Webinar - Upcoming PLE Study with Dr. Katie Tolbert, you can watch it at your convenience! The Webinar is now available on the SCWTCA website. If you own a Wheaten, get the knowledge from the expert! Watch it at https://scwtca.org/education/webinars/.

•November 2025 Wheaten Webinar • Dr. Ed Jazic Explains Bumps, Lumps, and Weird Growths

One of the most common questions breeders receive from owners are regarding those strange bumps, lumps and weird growths on their dog. It is always worrisome when they appear and some of them grow very fast. Some owners panic thinking their dog has cancer. There is no need to panic but it is important to understand them and know how to treat them. A bump on your Wheaten doesn’t automatically mean cancer. While skin bumps and strange lumps on dogs should always be taken seriously, certain types of bumps are more common than you might think, and they’re often harmless. Because this is such a common problem we are turning to Dr Ed Jazic, DVM DACVD (that means board certified canine dermatologist) for a one hour presentation and then a Q&A with participants.

Best of all your dog doesn’t have to be a Wheaten to attend. We love all dogs and want them well. So feel free to share this post. This webinar is free to you and graciously paid for by SCWTCA Health Endowment Inc. donors. You can send questions and photos in advance to health@scwtca.org....  We encourage participants to attend the live presentation as this is your opportunity to ask questions and receive answers from Dr. Jazic. The webinar will be recorded for future viewing.

Presenter: Dr. Ed Jazic

Sponsored by: SCWTCA Endowment, Inc.

Time: Nov. 18, 2025 06:00 PM Central Time (US and Canada)

If you didn't get a chance to watch the live Wheaten Webinar - Dr. Ed Jazic Explains Bumps, Lumps, and Weird Growths, you can watch it at your convenience! The Webinar is now available on the SCWTCA website. If you own a Wheaten, get the knowledge from the expert! Watch it at https://scwtca.org/education/webinars/.

*SCWTCA Health Endowment Annual Health & Database Newsletter November 2025!

Greetings Wheaten Owners:

Here we are again, at the end of another year. I do not know where the time goes. It seems like November sneaks up every year and I am making a New Year’s resolution to start this newsletter earlier. First and foremost, the Endowment team hopes this letter finds that you and your family (both two and four-legged) had a happy and healthy 2025 year. We know that we lost some of our great donors this year and some great Wheatens based on the tributes you made in your donation letters to us. When one of your Wheatens passes on, we find ourselves mourning our own Wheatens all over again as well as mourning with you. Your heartfelt tributes to them in your donation letters or on your social media pages are what keep us focused on supporting research and working hard for the breed we have all come to love.

Looking into the future, as is true with the start of every new year, we remain dedicated, enthusiastic and optimistic in fulfilling our mission to support and fund Wheaten health and research projects. This year breeders were faced with the realization that we have become an AKC Low Entry Breed. We have seen declining registrations for many years now but this was a big surprise. Every day is a new challenge in the preservation of our breed but one we take on with great enthusiasm and dedication. We have seen great improvements in the breed’s longevity because of our breeders’ and owners’ dedication to health.

Thank you for your continued support of the SCWTCA Health Endowment and

the SCWT Health and Pedigree Database. It is again, the National Day of Giving and we believe that means we exist to give back to you, your Wheatens and our breed. We are pleased to provide you

with our 2025 Winter Newsletter. Along with my New Year’s resolution to start this newsletter earlier, we hope you will make it your New Year’s resolution to create or update your Wheaten’s database records.

Consider giving this newsletter to your veterinarian or, if you are a breeder, forwarding it to your owners. Drop us an email at scwtca.endowment.inc@gmail.com if you would like us to mail one directly to them.

If you have any questions, please do not hesitate to contact us.

Link to Newsletter pdf

*SCWT Diet Study — Recruiting Healthy Soft-Coated Wheaten Terriers

We are recruiting for a study to evaluate how diet will benefit soft-coated wheaten terriers (SCWT), which are a breed known to be predisposed to chronic gastrointestinal (GI) disease. SCWTs are prone to developing severe GI signs. We have determined that SCWT develop changes in their gut before clinical signs develop. However, it is unknown if these changes are preventable with early diet intervention. The goal of this study is to determine if feeding a veterinary therapeutic diet will improve the GI health of SCWT.

PARTICIPATION

• Dogs will visit the hospital monthly for a total of 4 visits @ University of Wisconsin-Madison, Texas A&M University, Michigan State University, North Carolina State University, Adamstown Veterinary Hospital (Pennsylvania)

• Dogs will receive an Alicam® video capsule endoscope (VCE) twice, which they swallow like a pill and passes harmlessly in their stool

• Dogs will be transitioned to a kibble diet, which they will eat exclusively for 90 days

STUDY BENEFITS-FREE

• Free physical exam, blood work, fecal testing, vitamin testing, urinalysis and video capsule endoscopy

• Free high-quality diet with formulated nutrition plan for 3 months

INCLUSION CRITERIA – In order to participate in this study all dogs must:

• Weigh at least ~10 kg (~22 pounds)

• Be at least 1 year old

• NOT have chronic gastrointestinal (GI) disease or be on a GI or skin-specific diet

• NOT receive any any of the following medications: NSAID (carprofen), steroid (prednisone), gastric acid suppressant (Prilosec), antibiotics, anti-hypertensive/proteinuric/thrombotic medication

This study is generously funded in part by the Soft Coated Wheaten Terrier Club of America (SCWTCA) Endowment Inc.

For more information contact: kgrady@tamu.edu

*Recruiting Dogs with Chronic Kidney Disease — NC State College of Veterinary Medicine (IRIS Stage III or IV)

NC State University College of Veterinary Medicine is enrolling for a study to evaluate if gastrointestinal (GI) bleeding occurs more commonly in dogs with chronic kidney disease (CKD) compared to healthy dogs. Dog with CKD are commonly prescribed gastroprotectants, but these medications may be unwarranted and could be harmful. The goal of this study is to determine if dogs with CKD are more likely to have GI bleeding compared to healthy dogs using video capsule endoscopy (VCE), a safe and non-invasive way to evaluate the GI tract.

PARTICIPATION

• Dogs will be fasted the evening before and afternoon after capsule administration.

• Dogs will be administered an Alicam® video capsule endoscope (VCE).

• The VCE will pass harmlessly in the dog’s stool, be collected by the owner, and be returned to NCSU.

STUDY BENEFITS-FREE

• Free physical exam, blood work, urinalysis, urine culture, GI testing, fecal testing, and blood pressure measurements at screening appointment

• Free video capsule endoscopy of the entire GI tract

INCLUSION CRITERIA – In order to participate in this study all dogs:

• Must be diagnosed with late stage chronic kidney disease (IRIS III or IV)

o Creatinine > 2.9mg/dL on two separate occasions

o Urine specific gravity <1.015

• Weight is > 6.5kgs (14lbs)

• NOT have other systemic diseases (diabetes, hepatitis, GI disease)

• NOT using drugs associated with GI bleeding (NSAID, steroid, clopidogrel)

This study is generously funded by the Soft Coated Wheaten Terrier Club of America (SCWTCA).

For more information contact: Dr. Kylie Grady at kmgrady@ncsu.edu